Professor Kristen O’Halloran Cardinal, Biomedical Engineering, recently published work from her Cal Poly research lab in the journal Neuroradiology. The article, “Tissue-engineered aneurysm models for in vitro assessment of neurovascular devices,” included four student co-authors (Tiffany W. Shen, Brandon Puccini, Kristen Temnyk, Scott Herting) and described work that Cardinal’s team has been performing at Cal Poly over the past few years.
![Headshot of woman](https://ceng.calpoly.edu/wp-content/uploads/2019/04/Kristen.Cardinal-BMED-709x1024.jpg)
Abstract
Preclinical testing of neurovascular devices is crucial for successful device design and is commonly performed using in vivo organisms such as the rabbit elastase-induced aneurysm model; however, simple in vitro models may help further refine this testing paradigm. The purpose of the current work was to evaluate, and further develop, tissue-engineered blood vessel mimics (BVMs) as simple, early-stage models to assess neurovascular devices in vitro prior to animal or clinical use.